abstract：:Significant mitral regurgitation (MR) is frequent in patients with severe aortic stenosis (AS). In these cases, concomitant mitral valve repair or replacement is usually performed at the time of surgical aortic valve replacement (SAVR). Transcatheter aortic valve replacement (TAVR) has recently been considered as an a...

journal_title：Journal of the American College of Cardiology

authors： Nombela-Franco L,Ribeiro HB,Urena M,Allende R,Amat-Santos I,DeLarochellière R,Dumont E,Doyle D,DeLarochellière H,Laflamme J,Laflamme L,García E,Macaya C,Jiménez-Quevedo P,Côté M,Bergeron S,Beaudoin J,Pibarot P,Rodés-C

更新日期：2014-06-24 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine mortality and liver disease among patients exposed to dronedarone. BACKGROUND:There has been concern about the safety of dronedarone, especially for patients with heart failure and permanent atrial fibrillation (AF). There have also been suspicions about liver toxicity. ...

journal_title：Journal of the American College of Cardiology

authors： Friberg L

更新日期：2014-06-10 00:00:00

abstract：OBJECTIVES:The goal of this trial was to study the long-term effects of intravenous (IV) metoprolol administration before reperfusion on left ventricular (LV) function and clinical events. BACKGROUND:Early IV metoprolol during ST-segment elevation myocardial infarction (STEMI) has been shown to reduce infarct size whe...

journal_title：Journal of the American College of Cardiology

authors： Pizarro G,Fernández-Friera L,Fuster V,Fernández-Jiménez R,García-Ruiz JM,García-Álvarez A,Mateos A,Barreiro MV,Escalera N,Rodriguez MD,de Miguel A,García-Lunar I,Parra-Fuertes JJ,Sánchez-González J,Pardillos L,Nieto B,Jim

更新日期：2014-06-10 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine the association of SCN5A cardiac sodium (Na(+)) channel mRNA splice variants in white blood cells (WBCs) with risk of arrhythmias in heart failure (HF). BACKGROUND:HF is associated with upregulation of two cardiac SCN5A mRNA splice variants that encode prematurely trun...

journal_title：Journal of the American College of Cardiology

authors： Gao G,Brahmanandam V,Raicu M,Gu L,Zhou L,Kasturirangan S,Shah A,Negi SI,Wood MR,Desai AA,Tatooles A,Schwartz A,Dudley SC Jr

更新日期：2014-06-03 00:00:00

abstract：OBJECTIVES:This study sought to compare long-term survival after off- and on-pump coronary artery bypass grafting (CABG). BACKGROUND:Although several large-scale clinical trials have compared the surgical outcomes between off- and on-pump CABG, the long-term survival has not been compared between the 2 surgical strate...

journal_title：Journal of the American College of Cardiology

authors： Kim JB,Yun SC,Lim JW,Hwang SK,Jung SH,Song H,Chung CH,Lee JW,Choo SJ

更新日期：2014-06-03 00:00:00

abstract：OBJECTIVES:This study sought to investigate the prevalence of potentially abnormal electrocardiographic (ECG) patterns in young individuals to assess the implications for a nationwide screening program for conditions causing sudden cardiac death (SCD). BACKGROUND:The Italian experience suggests that pre-participation ...

journal_title：Journal of the American College of Cardiology

authors： Chandra N,Bastiaenen R,Papadakis M,Panoulas VF,Ghani S,Duschl J,Foldes D,Raju H,Osborne R,Sharma S

更新日期：2014-05-20 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine if ablation that targets patient-specific atrial fibrillation (AF)-sustaining substrates (rotors or focal sources) is more durable than trigger ablation alone at preventing late AF recurrence. BACKGROUND:Late recurrence substantially limits the efficacy of pulmonary ve...

journal_title：Journal of the American College of Cardiology

authors： Narayan SM,Baykaner T,Clopton P,Schricker A,Lalani GG,Krummen DE,Shivkumar K,Miller JM

更新日期：2014-05-06 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate 4-year outcomes and predictors of repeat revascularization in patients treated with the Resolute zotarolimus-eluting stent (R-ZES) (Medtronic, Minneapolis, Minnesota) and XIENCE V everolimus-eluting stent (EES) (Abbott Vascular, Abbott Park, Illinois) in the RESOLUTE (...

journal_title：Journal of the American College of Cardiology

authors： Taniwaki M,Stefanini GG,Silber S,Richardt G,Vranckx P,Serruys PW,Buszman PE,Kelbaek H,Windecker S,RESOLUTE All-Comers Investigators.

更新日期：2014-04-29 00:00:00

abstract：:Public reporting of hospital and individual provider quality of care measures is not a new concept. In the United States, the first national public reports of hospital mortality data occurred in 1986, and detailed physician-level data for cardiac surgery are now reported in 4 states. The development of the "Hospital C...

journal_title：Journal of the American College of Cardiology

authors： Dehmer GJ,Drozda JP Jr,Brindis RG,Masoudi FA,Rumsfeld JS,Slattery LE,Oetgen WJ

更新日期：2014-04-08 00:00:00

abstract：OBJECTIVES:This study sought to evaluate long-term in vivo functionality, host cell repopulation, and remodeling of "off-the-shelf" tissue engineered transcatheter homologous heart valves. BACKGROUND:Transcatheter valve implantation has emerged as a valid alternative to conventional surgery, in particular for elderly ...

journal_title：Journal of the American College of Cardiology

authors： Driessen-Mol A,Emmert MY,Dijkman PE,Frese L,Sanders B,Weber B,Cesarovic N,Sidler M,Leenders J,Jenni R,Grünenfelder J,Falk V,Baaijens FPT,Hoerstrup SP

更新日期：2014-04-08 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the safety and efficacy of the surgical versus transcatheter approach to correct perimembranous ventricular septal defects (pmVSDs) in a prospective, randomized, controlled clinical trial. BACKGROUND:pmVSD is a common congenital heart disease in children. Surgical...

journal_title：Journal of the American College of Cardiology

authors： Yang J,Yang L,Yu S,Liu J,Zuo J,Chen W,Duan W,Zheng Q,Xu X,Li J,Zhang J,Xu J,Sun L,Yang X,Xiong L,Yi D,Wang L,Liu Q,Ge S,Ren J

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:This study aimed to investigate the effect of both history of intermittent atrial tachyarrhythmias (IAT) and in-trial IAT on the risk of heart failure (HF) or death comparing cardiac resynchronization therapy with defibrillator (CRT-D) to implantable cardioverter-defibrillator (ICD) treatment in mildly sympt...

journal_title：Journal of the American College of Cardiology

authors： Ruwald AC,Pietrasik G,Goldenberg I,Kutyifa V,Daubert JP,Ruwald MH,Jons C,McNitt S,Wang P,Zareba W,Moss AJ

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:This study evaluated effects of protease-activated receptor-1 antagonist vorapaxar (Merck, Whitehouse Station, New Jersey) versus placebo among the TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) study patients with non-ST-segment elevation acute coronary syndrom...

journal_title：Journal of the American College of Cardiology

authors： Whellan DJ,Tricoci P,Chen E,Huang Z,Leibowitz D,Vranckx P,Marhefka GD,Held C,Nicolau JC,Storey RF,Ruzyllo W,Huber K,Sinnaeve P,Weiss AT,Dery JP,Moliterno DJ,Van de Werf F,Aylward PE,White HD,Armstrong PW,Wallentin

更新日期：2014-03-25 00:00:00

abstract：:The goal of this study was to review the prognostic value of cardiac magnetic resonance (CMR) imaging findings for future cardiovascular events in patients with a recent myocardial infarction (MI) and patients with suspected or known coronary artery disease (CAD). Although the diagnostic value of CMR findings is estab...

journal_title：Journal of the American College of Cardiology

authors： El Aidi H,Adams A,Moons KG,Den Ruijter HM,Mali WP,Doevendans PA,Nagel E,Schalla S,Bots ML,Leiner T

更新日期：2014-03-25 00:00:00

abstract：OBJECTIVES:The purpose of this study was to use cardiac magnetic resonance (CMR) imaging and invasive left ventricular (LV) pressure-volume (PV) measurements to explore the relationship between diffuse myocardial fibrosis and indexes of diastolic performance in a cohort of cardiac transplant recipients. BACKGROUND:The...

journal_title：Journal of the American College of Cardiology

authors： Ellims AH,Shaw JA,Stub D,Iles LM,Hare JL,Slavin GS,Kaye DM,Taylor AJ

更新日期：2014-03-25 00:00:00

abstract：:Chronic kidney disease (CKD) is increasingly prevalent in patients with chronic systolic heart failure. Therefore, evidence-based therapies are more and more being used in patients with some degree of renal dysfunction. However, most pivotal randomized clinical trials specifically excluded patients with (severe) renal...

journal_title：Journal of the American College of Cardiology

authors： Damman K,Tang WH,Felker GM,Lassus J,Zannad F,Krum H,McMurray JJ

更新日期：2014-03-11 00:00:00

abstract：OBJECTIVES:This study sought to evaluate the diagnostic performance of multiparametric cardiovascular magnetic resonance (CMR) for detecting cardiac allograft vasculopathy (CAV) using contemporary invasive epicardial artery and microvascular assessment techniques as reference standards, and to compare the performance o...

journal_title：Journal of the American College of Cardiology

authors： Miller CA,Sarma J,Naish JH,Yonan N,Williams SG,Shaw SM,Clark D,Pearce K,Stout M,Potluri R,Borg A,Coutts G,Chowdhary S,McCann GP,Parker GJ,Ray SG,Schmitt M

更新日期：2014-03-04 00:00:00

abstract：:Pre-clinical diastolic dysfunction (PDD) has been broadly defined as left ventricular diastolic dysfunction without the diagnosis of congestive heart failure (HF) and with normal systolic function. PDD is an entity that remains poorly understood, yet has definite clinical significance. Although few original studies ha...

journal_title：Journal of the American College of Cardiology

authors： Wan SH,Vogel MW,Chen HH

更新日期：2014-02-11 00:00:00

abstract：OBJECTIVES:This study examines whether the coronary artery calcium (CAC) score can be used to define the target population to treat with a polypill. BACKGROUND:Prior studies have suggested a single polypill to reduce cardiovascular disease (CVD) at the population level. METHODS:Participants from MESA (Multi-Ethnic St...

journal_title：Journal of the American College of Cardiology

authors： Bittencourt MS,Blaha MJ,Blankstein R,Budoff M,Vargas JD,Blumenthal RS,Agatston AS,Nasir K

更新日期：2014-02-11 00:00:00

abstract：OBJECTIVES:The goal of this study was to understand the role of genetic variation in the catecholamine biosynthetic pathway for control of human heart rate (HR). BACKGROUND:Human HR is an integrated cardiovascular trait predictive of morbidity and survival. Because the autonomic pathway exerts rapid control over the h...

journal_title：Journal of the American College of Cardiology

authors： Zhang K,Deacon DC,Rao F,Schork AJ,Fung MM,Waalen J,Schork NJ,Nievergelt CM,Chi NC,O'Connor DT

更新日期：2014-02-04 00:00:00

abstract：OBJECTIVES:This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects of pravastatin on TnI levels. BACKGROUND:The role of troponins in predicting long-term outcomes i...

journal_title：Journal of the American College of Cardiology

authors： White HD,Tonkin A,Simes J,Stewart R,Mann K,Thompson P,Colquhoun D,West M,Nestel P,Sullivan D,Keech AC,Hunt D,Blankenberg S,LIPID Study Investigators.

更新日期：2014-02-04 00:00:00

abstract：OBJECTIVES:The aim of this randomized placebo-controlled trial was to determine if withdrawing clopidogrel therapy leads to increased platelet activity compared with pre-treatment values in patients with stable coronary artery or peripheral arterial disease. BACKGROUND:Reports of increased cardiovascular events after ...

journal_title：Journal of the American College of Cardiology

authors： Ford I,Scott NW,Herd V,Mitchell LR,Williams DJ,Brittenden J

更新日期：2014-01-28 00:00:00

abstract：OBJECTIVES:This study aimed to identify the genetic defect in a family with idiopathic ventricular fibrillation (IVF) manifesting in childhood and adolescence. BACKGROUND:Although sudden cardiac death in the young is rare, it frequently presents as the first clinical manifestation of an underlying inherited arrhythmia...

journal_title：Journal of the American College of Cardiology

authors： Marsman RF,Barc J,Beekman L,Alders M,Dooijes D,van den Wijngaard A,Ratbi I,Sefiani A,Bhuiyan ZA,Wilde AA,Bezzina CR

更新日期：2014-01-28 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the pattern of the adoption of internal mammary artery (IMA) grafting in the United States, test its association with clinical outcomes, and assess whether its effectiveness differs in key clinical subgroups. BACKGROUND:The effect of IMA grafting on major clinical outcome...

journal_title：Journal of the American College of Cardiology

authors： Hlatky MA,Boothroyd DB,Reitz BA,Shilane DA,Baker LC,Go AS

更新日期：2014-01-07 00:00:00

abstract：:Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate. However, fundamental gaps remain in our understanding of the underlying pathological changes in pulmonary arteries and veins in the different forms of this syndrome. Although PH primarily affects the arteries, venous disease is incre...

journal_title：Journal of the American College of Cardiology

authors： Tuder RM,Archer SL,Dorfmüller P,Erzurum SC,Guignabert C,Michelakis E,Rabinovitch M,Schermuly R,Stenmark KR,Morrell NW

更新日期：2013-12-24 00:00:00

abstract：OBJECTIVES:The goal of this study was to examine the impact of calculation-window duration on lifespan gain (as observed in trials) and on who gains most. BACKGROUND:The landmark trials of biventricular pacing (cardiac resynchronization therapy [CRT]) typically ran for <1 device battery life, and they may therefore un...

journal_title：Journal of the American College of Cardiology

authors： Finegold JA,Raphael CE,Levy WC,Whinnett Z,Francis DP

更新日期：2013-12-24 00:00:00

abstract：OBJECTIVES:This study sought to ascertain whether high-dose allopurinol causes regression of left ventricular mass (LVM) in patients with type 2 diabetes mellitus (T2DM). BACKGROUND:Left ventricular hypertrophy (LVH) is common in T2DM and contributes to patients' high cardiovascular (CV) event rate. Oxidative stress (...

journal_title：Journal of the American College of Cardiology

authors： Szwejkowski BR,Gandy SJ,Rekhraj S,Houston JG,Lang CC,Morris AD,George J,Struthers AD

更新日期：2013-12-17 00:00:00

abstract：OBJECTIVES:This study sought to develop quality indicators (QIs) for outpatient management of adult congenital heart disease (ACHD) patients. BACKGROUND:There are no published QIs to promote quality measurement and improvement for ACHD patients. METHODS:Working groups of ACHD experts reviewed published data and Unite...

journal_title：Journal of the American College of Cardiology

authors： Gurvitz M,Marelli A,Mangione-Smith R,Jenkins K

更新日期：2013-12-10 00:00:00

abstract：OBJECTIVES:This study sought to determine the association between markers of cardiomyocyte injury in ambulatory subjects and sudden cardiac death (SCD). BACKGROUND:The pathophysiology of SCD is complex but is believed to be associated with an abnormal cardiac substrate in most cases. The association between biomarkers...

journal_title：Journal of the American College of Cardiology

authors： Hussein AA,Gottdiener JS,Bartz TM,Sotoodehnia N,deFilippi C,Dickfeld T,Deo R,Siscovick D,Stein PK,Lloyd-Jones D

更新日期：2013-12-03 00:00:00

abstract：OBJECTIVES:The aim of this study was to describe usage of the wearable cardioverter-defibrillator (WCD) during mandated waiting periods following myocardial infarction (MI) for patients perceived to be at high risk for sudden cardiac arrest (SCA). BACKGROUND:Current device guidelines and insurance coverage require wai...

journal_title：Journal of the American College of Cardiology

authors： Epstein AE,Abraham WT,Bianco NR,Kern KB,Mirro M,Rao SV,Rhee EK,Solomon SD,Szymkiewicz SJ

更新日期：2013-11-19 00:00:00

abstract：OBJECTIVES:This study sought to investigate the efficacy and safety of catheter ablation for atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFPEF). BACKGROUND:AF is a precipitating factor for clinical deterioration of HFPEF. METHODS:Catheter ablation for AF was performed in ...

journal_title：Journal of the American College of Cardiology

authors： Machino-Ohtsuka T,Seo Y,Ishizu T,Sugano A,Atsumi A,Yamamoto M,Kawamura R,Machino T,Kuroki K,Yamasaki H,Igarashi M,Sekiguchi Y,Aonuma K

更新日期：2013-11-12 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the significance of non-type 1 anterior early repolarization (NT1-AER) combined with inferolateral early repolarization syndrome (ERS). BACKGROUND:Inferolateral ERS might be a heterogeneous entity, although it excludes type 1 Brugada syndrome (BS). METHODS:Of 84 pat...

journal_title：Journal of the American College of Cardiology

authors： Kamakura T,Kawata H,Nakajima I,Yamada Y,Miyamoto K,Okamura H,Noda T,Satomi K,Aiba T,Takaki H,Aihara N,Kamakura S,Kimura T,Shimizu W

更新日期：2013-10-22 00:00:00

abstract：OBJECTIVES:The study objective was to validate a new high-sensitivity troponin I (hs-TnI) assay in a clinical protocol for assessing patients who present to the emergency department with chest pain. BACKGROUND:Protocols using sensitive troponin assays can accelerate the rule out of acute myocardial infarction in patie...

journal_title：Journal of the American College of Cardiology

authors： Cullen L,Mueller C,Parsonage WA,Wildi K,Greenslade JH,Twerenbold R,Aldous S,Meller B,Tate JR,Reichlin T,Hammett CJ,Zellweger C,Ungerer JPJ,Rubini Gimenez M,Troughton R,Murray K,Brown AFT,Mueller M,George P,Mosimann

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:This study sought to determine if nesiritide increases diuresis in congestive heart failure patients. BACKGROUND:In the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure), 7,141 patients hospitalized with acute decompensated heart failure (ADHF) were randomized t...

journal_title：Journal of the American College of Cardiology

authors： Gottlieb SS,Stebbins A,Voors AA,Hasselblad V,Ezekowitz JA,Califf RM,O'Connor CM,Starling RC,Hernandez AF

更新日期：2013-09-24 00:00:00

abstract：:Heart failure (HF) data in Latin America (LA) were reviewed to guide health service planning in the prevention and treatment of HF. The HF epidemiology and the adequacy of relevant health service provision related to HF in LA are not well delineated. A systematic search of the electronic databases and the World Health...

journal_title：Journal of the American College of Cardiology

authors： Bocchi EA,Arias A,Verdejo H,Diez M,Gómez E,Castro P,Interamerican Society of Cardiology.

更新日期：2013-09-10 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate the risk of thrombosis and bleeding according to multiple antithrombotic treatment regimens in atrial fibrillation (AF) patients after myocardial infarction (MI) or percutaneous coronary intervention (PCI). BACKGROUND:The optimal antithrombotic treatment strategy...

journal_title：Journal of the American College of Cardiology

authors： Lamberts M,Gislason GH,Olesen JB,Kristensen SL,Schjerning Olsen AM,Mikkelsen A,Christensen CB,Lip GY,Køber L,Torp-Pedersen C,Hansen ML

更新日期：2013-09-10 00:00:00

abstract：OBJECTIVES:This study prospectively evaluated the role of a novel 3-dimensional, noninvasive, beat-by-beat mapping system, Electrocardiographic Mapping (ECM), in facilitating the diagnosis of atrial tachycardias (AT). BACKGROUND:Conventional 12-lead electrocardiogram, a widely used noninvasive tool in clinical arrhyth...

journal_title：Journal of the American College of Cardiology

authors： Shah AJ,Hocini M,Xhaet O,Pascale P,Roten L,Wilton SB,Linton N,Scherr D,Miyazaki S,Jadidi AS,Liu X,Forclaz A,Nault I,Rivard L,Pedersen ME,Derval N,Sacher F,Knecht S,Jais P,Dubois R,Eliautou S,Bokan R,Strom M,

更新日期：2013-09-03 00:00:00

abstract：:The development of gestational diabetes and even milder forms of dysglycemia during pregnancy represents a maternal phenotype at increased subsequent risk for developing type 2 diabetes mellitus, metabolic syndrome, and, with time, overt cardiovascular disease. A careful and systematic dissection of the hormonal, meta...

journal_title：Journal of the American College of Cardiology

authors： Brewster S,Zinman B,Retnakaran R,Floras JS

更新日期：2013-08-20 00:00:00

abstract：:Obstructive sleep apnea (OSA) is an underdiagnosed condition characterized by recurrent episodes of obstruction of the upper airway leading to sleep fragmentation and intermittent hypoxia during sleep. Obesity predisposes to OSA, and the prevalence of OSA is increasing worldwide because of the ongoing epidemic of obes...

journal_title：Journal of the American College of Cardiology

authors： Drager LF,Togeiro SM,Polotsky VY,Lorenzi-Filho G

更新日期：2013-08-13 00:00:00

abstract：OBJECTIVES:The study sought to evaluate the effects of endurance exercise training (ET) on endothelial-dependent flow-mediated arterial dilation (FMD) and carotid artery stiffness, and their potential contributions to the training-related increase in peak exercise oxygen consumption (Vo2) in older patients with heart f...

journal_title：Journal of the American College of Cardiology

authors： Kitzman DW,Brubaker PH,Herrington DM,Morgan TM,Stewart KP,Hundley WG,Abdelhamed A,Haykowsky MJ

更新日期：2013-08-13 00:00:00